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PE -labeled mAb against human CDs - 500 µl for only 99 €, S-size (100 µl) for only 39 €, X2-size (2ml) for only 199€
For small size please place “S” behind the cat.no! Ajoutez “S” derrière la référence pour le petit emballage, s’il vous plaît!
Per favore aggiungete “S” dietro la referenza per l’imballagio piccolo! Bitte fügen Sie für die kleine Größe nach der Kat.Nr.“S” hinzu!
Por tamaño pequeño: Nº de catalogo + S, por favor!
For large size please place “X2” behind the cat.no! Ajoutez “X2” derrière la référence pour le grand emballage, s’il vous plaît!
Per favore aggiungete “X2” dietro la referenza per l’imballagio grande! Bitte fügen Sie für die große Größe nach der Kat.Nr.“X2” hinzu!
Por tamaño grande: Nº de catalogo + X2, por favor!
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Product
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Cat-No.
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Clone
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sub
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comments
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INFO
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CD1a
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21330014
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WM35
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IgG2b
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The antibody has been clusterd to CD1a on ine of the international Workshop on Human White Cell differentiation Antigens. The monoclonal antibody is directed against the CD1a-antigen, which is expressed on cortical thymocytes and certain thymomas in association with beta2-microglublin. The monoclonal antibody does not react with human granulocytes, monocytes, T- and B lymphocytes and NK-cells. The monoclonal antibody also reacts stronly with Langerhans cells.
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htm
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pdf
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CD3
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21270034
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MEM-57
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IgG2a
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Thymocytes; mature T cells; The antibody reacts with epsilon and delta chain of CD3 complex.
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htm
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pdf
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CD4
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21270044
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MEM-241
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IgG1
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The antibody reacts with CD4 antigen, a transmembrane glycoprotein (59 kDa) of the immunoglobulin supergene family present on subset of T lymphocytes (”helper/inducer” T cells) and also expressed at a lower level on monocytes and granulocytes.
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htm
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pdf
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CD5
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21270054
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MEM-32
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IgG1
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CD5 antigen
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htm
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pdf
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CD5
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21330054
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1C12
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IgG1
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This clone has been derived from hybridisation of SP2/0 cells with spleen cells of a BALB/c mouse immunised with cells of a patient with Sézary Syndrome. This antibody has been clustered to CD5 in one of the international Workshop on Human White Cell differentiation Antigens. The monoclonal antibody is directed against the CD5-antigen (T1-antigen), which is expressed on human T lymphocytes. The monoclonal antibody reacts with 90% of human peripheral T lymphocytes, medullary thymocytes as well as with lymphocytes of patients with chronic B-cell derived leukaemia. The antibody does not react with normal B-cells, monocytes, granulocytes and platelets.
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htm
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pdf
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CD8
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21270084
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MEM-31
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IgG2a
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The antibody recognizes a conformationally-dependent epitope of CD8 antigen (does not react with formaldehyde-fixed cells; negative in Western Blotting application)
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htm
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pdf
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CD10
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21279104
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LT10
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IgG1
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The antibody reacts with human CD10 antigen (CALLA).
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htm
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pdf
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CD10
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21330104
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4F9
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IgG2a
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This clone has been derived from hybridisation of SP2/0 cells with spleen cells of a (BALB/c x A/J) mouse immunised with cells of a patient with Acute Lymphocytic Leukaemia of the c-ALL type. This antibody has been clustered to CD10 in one of the international Workshop on Human White Cell differentiation Antigens. The monoclonal antibody is directed against the CD10-antigen (CALL-antigen), which is expressed on human lymphoblasts. The antibody reacts with early B lymphocytes (stem-cell, pre-B) and with the stem-cell of the lymphocyte lineage and immature thymocytes. Lymphoblasts of a patient with an Acute Lymphocytic Leukaemia of the c-ALL type were found to be positive. Normal B- and T lymphocytes, monocytes and platelets were found to be negative.
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htm
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pdf
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CD11a
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21270114
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MEM-25
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IgG1
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The antibody reacts with alpha-subunit (CD11a) of human LFA-1 (AlphaL integrin chain).
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htm
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pdf
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CD11b
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21279114
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MEM-174
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IgG2a
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The antibody reacts with the antigen 11b.(Mac-1)
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htm
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pdf
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CD13
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21270134
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WM15
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IgG1
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The antibody regognises the human CD13 cell surface glycoprotein, a 150kD molecule expressed on granulocytes, endothelial cells, epithelial cells and myeloid progenitors.
Immunogen: human AML cells
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htm
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pdf
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CD13
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21330134
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Q20
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IgG2a
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This clone has been derived from hybridization of SP2/0 cells with spleen cells of a BALB/c mouse immunized with human myeloblasts of a chronic myeloïd leukaemia patient in blast crisis. This antibody has been clustered to CD13 in the third International Workshop on Human White Cell differentiation Antigens in Oxford (1986). The monoclonal antibody is directed against the CD13-antigen, which is expressed on human monocytes, granulocytes and their precursors. The monoclonal antibody reacts with monocytes, granulocytes and with a large number of acute myeloïd leukaemias (the positivity of this marker relates to worse clinic prognosis).
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htm
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pdf
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CD14
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21270144
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MEM-18
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IgG1
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Monocytes; macrophages; granulocytes
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htm
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pdf
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CD14
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21330144
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8G3
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IgG2a
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This clone has been derived from hybridisation of SP2/0 cells with spleen cells of a BALB/c mouse immunised with human monocytes. This antibody has been clustered to CD14 in the Third International Workshop on Human White Cell differentiation Antigens in Oxford (1986). The monoclonal antibody is directed against the CD14-antigen, which is expressed on human monocytes and macrophages. The antibody reacts with human monocytes and macrophages; weak reactions may occur with neutrophils.
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htm
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pdf
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CD16
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21279164
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LNK16
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IgG1
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The antibody reacts with CD16 antigen that functions as a low affinity receptor for aggregated IgG (FcgammaRIII antigen). CD16 antigen exists in two different isoforms: CD16a is a transmembrane form (50-65 kDa) expressed on NK cells, monocytes and macrophages; CD16b is a GPI-anchored form (48 kDa) mainly expressed on neutrophils. Very useful for NK-cell characterisation
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htm
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pdf
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CD16
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21330164
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5D2
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IgG2a
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This clone has been derived from hybridisation of SP2/0 cells with spleen cells of a BALB/C mouse immunised with human granulocytes. This antibody has been clustered to CD16 in one of the international Workshop on Human White Cell differentiation Antigens. The monoclonal antibody is directed against the CD16-antigen (the Fc gamma Receptor III), which is expressed on granulocytes, NK lymphocytes and macrophages (2, 4). The mobility of the CD16-antigen is dependent on the NA1/NA2 allotype of the neutrophil donor (3). The monoclonal antibody inhibits the binding of human IgG to the Fc gamma Receptor III (1, 4)
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htm
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pdf
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CD19
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21270194
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LT19
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IgG1
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CD19 antigen
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htm
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pdf
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CD20
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21279204
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LT20
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IgG2a
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CD20 antigen
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htm
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pdf
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CD22
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21270224
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MEM-01
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IgG1
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CD22 antigen. The antibody MEM-01 cross-blocks the antibody OTH228 that recognizes uniquely epitope "E"; it does not cross-block antibodies RFB-4, CLB22/1 and CLB-BLy1.
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htm
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pdf
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CD22
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21330224
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6B11
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IgG1
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The antibody was submitted to CD22 in the Third International Workshop on Human Leukocyte Differentiation Antigens. The monoclonal antibody is directed against the CD22 antigen (Bgp135), which is expressed on precursor B cells (cytoplasmatics) and subset of mature B cells (membrane) (molecular mass 130-140 kDa). Normal T cells, polymorph nuclear cells, monocytes and platelets were found to be negative. Cell lines SB, Raji and NALM-1 were found to be positive. Most CALLA-ALL were found to be positive. The reaction pattern to CLL and NHL is variable from weak to negative. PLL is clearly positive and Hairy Cell Leukaemia is very strong positive with this antibody.
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htm
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pdf
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CD25
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21330254
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TB30
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IgG2b
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This clone has been derived from hybridization of SP2/0 cells with spleen cells of a BALB/c mouse immunized with PHA stimulated T lymphocytes. This antibody has been clustered to in one of the international Workshop on Human White Cell differentiation Antigens. The monoclonal antibody is directed against the CD25-antigen (Interleukin-2 receptor). The monoclonal antibody binds selectively to activated human lymphoblasts. Resting human blood cells were found to be negative. The monoclonal antibody is able to inhibit IL-2 driven T-cell proliferation.
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htm
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pdf
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CD33
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21330334
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MD33.6
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IgG1
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This clone has been derived from hybridization of SP2/0 cells with spleen cells of a BALB/c mouse immunized with human CD33 transfectants. This antibody has been clustered to CD33 in one of the international Workshop on Human White Cell differentiation Antigens. The monoclonal antibody is directed against the CD33-antigen (belonging to the Ig-supergene family), which is expressed on human myelomonocytic cells. The monoclonal antibody reacts in the bone marrow from myeloblasts up to myelocytes. CD33-antigen is found on CFU-GEMM, CFU-GM, CFU-G, CFU-M and with erythroid CFU-E but not on earlier precursors. The monoclonal antibody does not react with normal human peripheral granulocytes, B-cells, T-cells and platelets. The monoclonal antibody reacts weakly with blast cells in 70% of patients with Acute Myeloid Leukaemia (AML) and in 30% of adult patients with Acute Lymphoblastic Leukaemia (ALL).
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htm
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pdf
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CD34
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21270344
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4H11[APG]
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IgG1
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The antibody reacts with Class III epitope on CD34 antigen.The antibody 4H11[APG] completely blocks binding of Class II antibody QBEnd10 and Class III antibodies BIRMA K3 and 8G12 on KG1a cell line.
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htm
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pdf
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CD38
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21330384
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HIT2
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IgG1
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The monoclonal antibody is directed against the CD38 antigen, which is strongly expressed on plasma cells. The CD38-antigen is also expressed on activated T-cells, terminally differentiated B-cells, early B-cells, monocytes, multiple myelomas, most cases of ALL (both T and B lineage), and some AML. The CD38-antigen is a single-chain Type II transmembrane protein.
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htm
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pdf
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CD41a
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21330414
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DD4.1
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IgG1
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This clone has been derived from hybridization of NS1-cells with spleen cells of a BALB/c mouse immunised with medulloblastoma tissue. The monoclonal react with megakaryocytes, platelets and recognize the intact thrombocyte GPIIb/IIIa complex, i.e. it does not bind to dissociated GPIIb or GPIIIa. The monoclonal antibodies do not bind or reduced to thrombocytes from patients with Glanzmann´s thrombasthenia and do not recognize the vitronection receptor, which contains GPIIa as a beta subunit.
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htm
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pdf
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CD41
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21270414
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MEM-06
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IgG1
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CD41 antigen.
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htm
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pdf
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CD42b
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21330424
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MB45
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IgG1
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This clone has been derived from hybridization of SP2/0 cells with spleen cells of a BALB/c mouse immunized with human platelets. This antibody has been clustered to CD42b in the fourth international Workshop on Human White Cell differentiation Antigens in Vienna (1989). The monoclonal antibody is directed against the CD42b-antigen (gplb), which is expressed on human thrombocytes and megakaryocytes.
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htm
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pdf
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CD45
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21270454
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MEM-28
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IgG1
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The antibody reacts with all alternative forms of CD45 antigen (Leucocyte common antigen).
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htm
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pdf
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CD45
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21330454
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15D9
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IgG1
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This clone has been derived from hybridisation of SP2/0 cells with spleen cells of a BALB/c mouse immunised with human thymocytes obtained after corrective cardiac surgery. This antibody has been clustered to CD45 in one of the international Workshop on Human White Cell differentiation Antigens. The monoclonal antibody is directed against the CD45-antigen, defined T200 or Leucocyte Common Antigen. The antibody reacts with all cells of the haemopoietic lineage, not with cells of other lineage’s.
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htm
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pdf
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CD45RA
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21279454
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MEM-56
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IgG2b
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CD45RA antigen
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htm
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pdf
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CD45RA
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21339454
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F8-11-13
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IgG1
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This antibody has been clustered to CD45RA in one of the international Workshop on Human White Cell differentiation Antigens. The monoclonal antibody is directed against the CD45RA-antigen (restricted T200), a component of the Leucocyte Common Antigen (LCA) complex, which is expressed on human B lymphocytes, monocytes and some CD4 or CD8 positive T lymphocytes. The monoclonal antibody reacts weakly with thymocytes. The monoclonal antibody does not react with human granulocytes and plasma cells.
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htm
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pdf
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CD45RB
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21278454
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MEM-55
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IgG1
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The antibody recognizes a siliadase-sensitive epitope of CD45RB antigen
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htm
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pdf
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CD46
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21270464
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MEM-258
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IgG1
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The antibody recognizes an epitope on SCR4(the membrane-proximal SCR) domain of CD46 antigen(Membrane cofactor protein)
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htm
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pdf
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CD54
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21279544
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1H4
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IgG2b
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ICAM-1 (Mw 90 kD) is a member of the C2 subset of immunoglobulin superfamily. It is a transmembrane molecule with 7 potential N-glycosylated sites, expressed on resting monocytes and endothelial cells and can be upregulated on many other cells, e.g. with lymphokines, on B- and T-lymphocytes, thymocytes, dendritic cells and also on keratinocytes, chondrocytes, as well as epithelial cells.
CD54 mediates cell adhesion by binding to integrins CD11a/CD18 (LFA-1) and to CD11b/CD18(Mac-1). the interaction of CD54 with LFA-1 enhances antigen-specific T-cell activation.
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htm
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pdf
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CD56
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21270564
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MEM-188
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IgG2a
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CD56 antigen (human). MEM-188 reacts with 180 kDa isoform characteristic for leucocytes. Reactivity with other NCAM isoforms has not been tested.
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htm
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pdf
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CD56
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21330564
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B159
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IgG1
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This antibody has been clustered to CD56 in one of the international Workshop on Human White Cell differentiation Antigens. The monoclonal antibody is directed against the heavily glycosylated CD56-antigen, (an isoform of N-CAM), which is expressed on human NK-cells. The monoclonal antibody does not react with human granulocytes, monocytes and B lymphocytes.
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htm
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pdf
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CD62P
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21330624
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C2
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IgG1
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This clone has been derived from hybridisation of SP2/0 Ag14 cells with spleen cells of a (BALB/c x A/J) mouse immunised with human platelets. This antibody has been clustered to CD62P in the fifth international Workshop on Human White Cell differentiation Antigens in Boston (1993). The monoclonal antibody is directed against the CD62P-antigen (GMP-140 or PADGEM), which is expressed in platelet alpha granules, which is translocated to the platelet surface upon activation with strong agonists. A similar protein, derived from endothelial cell Weibel-Palade bodies, is transiently expressed on the surface of activated endothelial cells.
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htm
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pdf
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CD63
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21270634
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MEM-259
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IgG1
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The antibody reacts with CD63 antigen (Melanoma 1 antigen), a glycoprotein of 40-60 kDa belonging to tetraspans family (TM4SF). CD63 is intracellular lysosomal/endosomal/granule protein that is translocated to cell surface surface upon activation of platelets, endothelial cells, and granulocytes (activation marker). CD63 is also expressed on monocytes/macro-phages and endothelium. Its cellular function has not been exactly elucidated. CD63 is thought to be associated with the early stages of melanoma tumor progression (in regulation of motility and adhesion of melanoma cells).
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htm
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pdf
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CD63
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21330634
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435
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IgG1
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This clone has been derived from hybridization of SP2/0 cells with spleen cells of a (BALB/c x A/J) mouse immunized with human cytochrome-B enriched cells. This antibody has been clustered to CD63 in the fourth international Workshop on Human White Cell differentiation Antigens in Vienna (1989). The monoclonal antibody is directed against the CD63-antigen, which is expressed in platelet lysosomes that is translocated to the platelet surface upon activation with strong agonists. The antigen is also present in most peripheral blood cells (not in erythrocytes) and in many tissues; both surface and cytoplasmatic locations are reported.
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htm
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pdf
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CD66acde
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21330664
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IH4Fc
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IgG1
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The monoclonal antibody is directed against the CD66acde-antigen, which is expressed on mature human granulocytes. After granulocyte activation the expression is strongly increased. The monoclonal antibody reacts with 100% of mature human peripheral granulocytes. It reacts weak with malignant cells of patients with B-cell derived Chronic Lymphoid Leukaemia (CLL). The monoclonal antibody does not react with normal human peripheral B-cells, T-cells, monocytes and platelets. In immunohistology the monoclonal antibody reacts with some tissue macrophages and CEA, the Carcino Embryonic Antigen expressed on colon carcinoma and other carcinomas.
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htm
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pdf
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CD69
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21330694
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TP1.55.3
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IgG2b
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This clone has been derived from hybridization of X63/Ag8.653 with spleen cells of a BALB/c mouse immunized with human PBL activated for 24 hours with PMA andanti-CD3 monoclonal antibody. This antibody has been clustered to CD69 in one of the international Workshops on Human Leucocyte Differentiation Antigens. The monoclonal antibody is directed against the CD69 antigen which is constitutively expressed on a subpopulation of thymocytes and platelets (4). The CD69 molecule (also designated as activation inducer molecule (AIM)), is a phosphorylated disulfide-linked 27/33 kDa homodimer composed of differently glycosylated subunits. CD69 is a type II integral membrane protein with an extracellular C-type lectin domain (1). Upon activiation of T-, NK- and B-cells in vitro CD69 is the earliest inducible cell surface glycoprotein to appear. CD69 is involved in signal transduction during the initial steps of cell activation. CD69 is undetectable on most circulating pheripheral blood lymphocytes (2). Resting T-cells do not express CD69 but its expression may be rapidly induced by triggering the TCR/CD3 complex. The majority of peripheral blood NK-cells are negative for CD69, but they express AIM shortly after activiation with PMA, IL-2, alfa-interferon or CD16 monoclonal antibody (3). In NK-cells and platelets CD69 acts as a triggering molecule. TP1.55.3 reacts with activated T lymphocytes but has a weak or no effect on the induction of T-cell proliferation and IL-2 production, respectively (2). This monoclonal antibody immunoprecipitates the 60 kDa homodimer and both 27 kDa and 33 kDa subunits from PBL activated (with PMA and anti-CD3 mAbs) under reduced and non-reduced conditions, repectively (2).
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htm
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pdf
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CD71
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21270714
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MEM-75
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IgG1
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The antibody reacts with CD71 antigen (transferrin receptor). The antibody does not block of transferrin to the receptor.
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htm
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pdf
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CD71
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21330714
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RVS10
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IgG1
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This clone has been derived from hybridization of NS1 cells with spleen cells of a BALB/c mouse immunized with cells of NALM-6 cell line. This antibody has been clustered to CD71 in one of the international Workshop on Human White Cell differentiation Antigens. The monoclonal antibody is directed against the CD71-antigen, human transferrin receptor, which is expressed on activated T and B lymphocytes and monocytes. The monoclonal antibody does not react with human granulocytes, T and B lymphocytes and NK cells.
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htm
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pdf
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CD138
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21331384
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1D4
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IgG1
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This clone has been derived from hybridisation of SP2/0 cells with spleen cells of a BALB/c mouse immunised with a myeloma cell line (TH). The monoclonal antibody is directed against an specific antigen for plasmacells. It strongly binds to plasma cells lines, including TH (the immunising cell line) and RPMI 8226. Moderate binding is seen to EBV-transformed lymphoblastoid cell lines. The antibody does not react with other lymphoid cells, including normal and leukemic B-cells. The antibody does not effect the proliferation and Ig-production of plasma cell lines.
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htm
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pdf
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CD235a
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21272354
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HIR2
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IgG2b
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The antibody recognizes N-terminal, homologous portion of glycophorins A(GPA) and BGPB) which are single-pass membrane sialoglycoproteins. GPA is the carrier of blood group M and N specificities, while GPB accounts for S, s and U specificities. GPA and GPB provide the cells with a large mucin-like surface and it has been suggested this provides a barrier to cell fusion, so minimizing aggregation between red blood cells in the circulation. The antibody agglutinates untreated RBCs but it failes to agglutinate papain-treated cells. The antibody HIR2 significantly binds to GPA, but weakly to GPB. The antibody is useful in erythroid cell development studies, because HIR2 antigen is expressed on early erytroblasts, late erythroblasts, erythroblasts, mature erythrocytes and the cells of erythroid cell lines K562 and HEL, but not on all other cells(mature erythrocytes are characteristically CD235a positive and CD45 and CD71 negative).
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htm
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pdf
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CD235a
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21332354
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AME-1
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IgG1
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This clone has been derived from hybridization of SP2/0 cells with spleen cells of a BALB/c mouse immunized with human erythrocytes. This antibody has been clustered to in the seventh international Workshop on Human White Cell differentiation Antigens. The monoclonal antibody is directed against the alpha-chain of glycophorin. In direct agglutination tests this monoclonal antibody reacts with normoblasts and erythrocytes. No reaction occurs with En(a-) erythrocytes and other normal peripheral blood cells.
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htm
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pdf
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control IgG1
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21275014
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PFR-01
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IgG1
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Pytophthora (strawberry pathogen)
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htm
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pdf
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control IgG1
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21275514
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PPV-06
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IgG1
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This monoclonal antibody reacts with undefined epitope on a plant pathogen.
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htm
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pdf
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control IgG1
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21335014
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203
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IgG1
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This monoclonal control is directed against plant allergens. There is no reactivity with human blood cells and immunoglobulins.
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htm
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pdf
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control IgG2a
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21275524
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PPV-04
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IgG2a
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none
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htm
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pdf
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control IgG2a
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21335024
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713
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IgG2a
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This monoclonal control is isolated from non-immunized mouse. There is no reactivity with human blood cells and immunoglobulins.
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htm
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pdf
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control IgG2b
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21275034
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PFR-02
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IgG2b
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Pytophthora (strawberry pathogen)
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htm
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pdf
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control IgG2b
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21335034
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GC198
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IgG2b
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This monoclonal antibody reacts with the outermembrane protein of some strains of Neisseria gonorrhoea. No reaction with human cell surface or plasma components has been observed. However, some binding to Fc receptors may occur.
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htm
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pdf
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control IgG3
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21275044
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PPV-07
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IgG3
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This antibody reacts with undefined epitope on a plant pathogen.
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htm
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pdf
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Granzyme B
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21144014
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HC4
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IgG1
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Granzyme B This clone has shown to be suitable for flowcytometry with intracellular staining.
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htm
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pdf
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Granzyme B
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21334014
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GB11
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IgG1
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Granzyme B This clone has shown to be suitable for flowcytometry with intracellular staining.
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htm
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pdf
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HLA-ABC
|
21159034
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W6/32HLK
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IgG2a
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The anti-human HLA-ABC monoclonal antibody recognizes an epitope common among 43 kDa chains of the HLA-ABC antigens. These antigens appear an virtually every human nucleated cell. This antibody is suitble as a positive control for HLA tissue typing and crossmatching.
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htm
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pdf
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HLA-DR
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21278994
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MEM-15
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IgG1
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The antibody recognizes common epitope on human HLA-DR which is dependent on the association of alpha and beta chains.
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htm
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pdf
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IFN-gamma
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21273534
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G-23
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IgG1
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The antibody reacts with IFN-gamma, a 20-25 kDa cytokine produced by activated Th1 cells and NK cells.
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htm
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pdf
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Perforin
|
21146094
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deltaG9
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IgG2b kappa
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Human perforin (cytolysin) is balieved to be one of the major effector molecules used by cytotoxic Tcells and NK cells to mediate targeted cell lysis. Perforin expression is constitutive on NK Cells, but increases in resting CD8+ cytotoxic cells upon activation. Antibody deltaG9 recognizes the human perforin molecule of 70 kd.
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htm
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pdf
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